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For recent list of publications, please visit Publication list (PubMed) or Scholar page.

Bhute VJ, Palecek SP (2015). Metabolic responses induced by DNA damage and poly (ADP-ribose) polymerase (PARP) inhibition in MCF-7 cells. Metabolomics, 11:1779-1791.

Cossette, S. M., Gastonguay, A. J., Bao, X., Lerch-Gaggl, A., Zhong, L., Harmann, L. M., ... & Ramchandran, R. (2015). Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Biology open, 4(1), 48-61.

Laperle, A., Masters, K. S., & Palecek, S. P. (2014). Influence of substrate composition on human embryonic stem cell differentiation and extracellular matrix production in embryoid bodies. Biotechnology progress.

Lian, X., Bao, X., Al-Ahmad, A., Liu, J., Wu, Y., Dong, W., ... & Palecek, S. P. (2014). Efficient Differentiation of Human Pluripotent Stem Cells to Endothelial Progenitors via Small-Molecule Activation of WNT Signaling. Stem cell reports, 3(5), 804-816.

Hsiao, C., Tomai, M., Glynn, J. and Palecek, S. P. (2014), Effects of 3-D microwell culture on initial fate specification in human embryonic stem cells. AIChE J., 60: 1225-1235.

Musah, S., Wrighton, P. J., Zaltsman, Y., Zhong, X., Zorn, S., Parlato, M. B., ... & Kiessling, L. L. (2014). Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification. Proceedings of the National Academy of Sciences, 111(38), 13805-13810.

Wilson, H. K., Canfield, S. G., Shusta, E. V., & Palecek, S. P. (2014). Concise Review: Tissue?Specific Microvascular Endothelial Cells Derived From Human Pluripotent Stem Cells. Stem Cells, 32(12), 3037-3045.

Raman, N., Lee, M. R., Palecek, S. P., & Lynn, D. M. (2014). Polymer multilayers loaded with antifungal beta-peptides kill planktonic Candida albicans and reduce formation of fungal biofilms on the surfaces of flexible catheter tubes. Journal of Controlled Release, 191, 54-62.

Lee, M. R., Raman, N., Gellman, S. H., Lynn, D. M., & Palecek, S. P. (2014). Hydrophobicity and Helicity Regulate the Antifungal Activity of 14-Helical beta-Peptides. ACS chemical biology, 9(7), 1613-1621.

Liu, R., Chen, X., Falk, S. P., Mowery, B. P., Karlsson, A. J., Weisblum, B., ... & Gellman, S. H. (2014). Structure-Activity Relationships among Antifungal Nylon-3 Polymers: Identification of Materials Active against Drug-Resistant Strains of Candida albicans. Journal of the American Chemical Society, 136(11), 4333-4342.

2012

Powers A.D., Liu B., Lee A.G. and Palecek S.P. (2012). Macroporous hydrogel micropillars for quantifying Met kinase activity in cancer cell lysates. Analyst. 137:4052-61.

Lippmann E.S., Azarin S.M., Kay J.E., Nessler R.A., Wilson H.K., Al-Ahmad A., Palecek S.P. and Shusta EV. (2012). Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells. Nat Biotechnol. 30:783-791.

Hazeltine L.B., Simmons C.S., Salick M.R., Lian X., Badur M.G., Han W., Delgado S.M., Wakatsuki T., Crone W.C., Pruitt B.L. and Palecek S.P. (2012). Effects of substrate mechanics on contractility of cardiomyocytes generated from human pluripotent stem cells. Int J Cell Biol. (2012):508294.

Lian X., Hsiao C., Wilson G., Zhu K., Hazeltine L.B., Azarin S.M., Raval K.K., Zhang J., Kamp T.J. and Palecek SP. (2012). Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci U S A. 109:1848-57.

Ghosh G., Lian X., Kron S.J. and Palecek S.P. (2012). Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors. BMC Cancer. 12:95.

Azarin S.M., Lian X., Larson E.A., Popelka H.M., de Pablo J.J. and Palecek S.P. (2012). Modulation of Wnt/β-catenin signaling in human embryonic stem cells using a 3-D microwell array. Biomaterials. 33:2041-9.

Lee A.G., Beebe D.J. and Palecek S.P. (2012). Quantification of kinase activity in cell lysates via photopatterned macroporous poly(ethylene glycol) hydrogel arrays in microfluidic channels. Biomed Microdevices. 14:247-57.

2011

Broderick A.H., Azarin S.M., Buck M.E., Palecek S.P. and Lynn D.M. (2011). Fabrication and selective functionalization of amine-reactive polymer multilayers on topographically patterned microwell cell culture arrays. Biomacromolecules. 12:1998-2007.

Lee A.G., Arena C.P. and Palecek, S.P. 2010. Development of macroporous poly(ethylene glycol) hydrogel arrays within microfluidic channels. Biomacromolecules. 11:3316-24.

2010

Azarin, S. M., and Palecek, S.P. 2010. Development of scalable culture systems for human embryonic stem cells. Biochem. Eng. J. 48:378-384. doi: 10.1016/j.bej.2009.10.020.

Azarin, S. M., and Palecek, S.P. 2010. Matrix Revolutions: A Trinity of Defined Substrates for Long-Term Expansion of Human ESCs. Cell Stem Cell. 7:7-8. doi: 10.1016/j.stem.2010.06.008.

Ghosh, G., X. Yan, A. G. Lee, S. J. Kron, and Palecek, S.P. 2010. Quantifying the sensitivities of EGF receptor (EGFR) tyrosine kinase inhibitors in drug resistant non-small cell lung cancer (NSCLC) cells using hydrogel-based peptide array. Biosens. Bioelectron. 26:424-431. doi: 10.1016/j.bios.2010.07.106.

Karlsson, A. J., R. M. Flessner, S. H. Gellman, D. M. Lynn, and Palecek, S.P. 2010. Polyelectrolyte Multilayers Fabricated from Antifungal beta-Peptides: Design of Surfaces that Exhibit Antifungal Activity Against Candida albicans. Biomacromolecules. 11:2321-2328. doi: 10.1021/bm100424s.

Lee, A. G., C. P. Arena, D. J. Beebe, and Palecek, S.P. 2010. Development of Macroporous Poly(ethylene glycol) Hydrogel Arrays within Microfluidic Channels. Biomacromolecules. 11:3316-3324. doi: 10.1021/bm100792y.

Metallo, C. M., S. M. Azarin, L. E. Moses, L. Ji, J. J. de Pablo, and Palecek, S.P. 2010. Human Embryonic Stem Cell-Derived Keratinocytes Exhibit an Epidermal Transcription Program and Undergo Epithelial Morphogenesis in Engineered Tissue Constructs. Tissue Engineering Part a. 16:213-223. doi: 10.1089/ten.tea.2009.0325.

Mohr, J. C., J. Zhang, S. M. Azarin, A. G. Soerens, J. J. de Pablo, J. A. Thomson, G. E. Lyons, Palecek, S.P., and T. J. Kamp. 2010. The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells. Biomaterials. 31:1885-1893. doi: 10.1016/j.biomaterials.2009.11.033.

2009

Ghosh, G., A. G. Lee, and Palecek, S.P. 2009. Hydrogel-based protein array for quantifying epidermal growth factor receptor activity in cell lysates. Anal. Biochem. 393:205-214. doi: 10.1016/j.ab.2009.07.002.

Karlsson, A. J., W. C. Pomerantz, K. J. Neilsen, S. H. Gellman, and Palecek, S.P. 2009. Effect of Sequence and Structural Properties on 14-Helical beta-Peptide Activity against Candida albicans Planktonic Cells and Biofilms. Acs Chemical Biology. 4:567-579. doi: 10.1021/cb900093r.

Nie, Y., V. Bergendahl, D. J. Hei, J. M. Jones, and Palecek, S.P. 2009. Scalable Culture and Cryopreservation of Human Embryonic Stem Cells on Microcarriers. Biotechnol. Prog. 25:20-31. doi: 10.1021/bp.110.

2008

Benton, M. G., N. R. Glasser, and Palecek, S.P. 2008. Deletion of MAG1 and MRE11 enhances the sensitivity of the Saccharomyces cerevisiae HUG1P-GFP promoter-reporter construct to genotoxicity. Biosens. Bioelectron. 24:736-741. doi: 10.1016/j.bios.2008.06.033.

Li, F., and Palecek, S.P. 2008. Distinct domains of the Candida albicans adhesin Eap1p mediate cell-cell and cell-substrate interactions. Microbiology-Sgm. 154:1193-1203. doi: 10.1099/mic.0.2007/013789-0.

McDevitt, T. C., and Palecek, S.P. 2008. Innovation in the culture and derivation of pluripotent human stem cells. Curr. Opin. Biotechnol. 19:527-533. doi: 10.1016/j.copbio.2008.08.005.

Metallo, C. M., S. M. Azarin, L. Ji, J. J. de Pablo, and Palecek, S.P. 2008. Engineering tissue from human embryonic stem cells. J. Cell. Mol. Med. 12:709-729. doi: 10.1111/j.1582-4934.2008.00228.x.

Metallo, C. M., L. Ji, J. J. De Pablo, and Palecek, S.P. 2008. Retinoic acid and bone morphogenetic protein signaling synergize to efficiently direct epithelial differentiation of human embryonic stem cells. Stem Cells. 26:372-380. doi: 10.1634/stemcells.2007-0501.

Metallo, C. M., M. A. Vodyanik, J. J. de Pablo, I. I. Slukvin, and Palecek, S.P. 2008. The response of human embryonic stem cell-derived endothelial cells to shear stress. Biotechnol. Bioeng. 100:830-837. doi: 10.1002/bit.21809.

Saha, S., L. Ji, J. J. de Pablo, and Palecek, S.P. 2008. TGF beta/Activin/Nodal pathway in inhibition of human embryonic stem cell differentiation by mechanical strain. Biophys. J. 94:4123-4133. doi: 10.1529/biophysj.107.119891.

2007

Benton, M. G., N. R. Glasser, and Palecek, S.P. 2007. The utilization of a Saccharomyces cerevisiae HUG1P-GFP promoter-reporter construct for the selective detection of DNA damage. Mutat. Res. -Genet. Toxicol. Environ. Mutag. 633:21-34. doi: 10.1016/j.mrgentox.2007.05.002.

Metallo, C. M., L. Ji, J. J. De Pablo, and Palecek, S.P. 2007. BIOT 33-Generation and characterization of keratinocytes from human embryonic stem cells. Abstracts of Papers of the American Chemical Society. 234:33-BIOT.

Li, F., M. J. Svarovsky, A. J. Karlsson, J. P. Wagner, K. Marchillo, P. Oshel, D. Andes, and Palecek, S.P. 2007. Eap1p, an adhesin that mediates Candida albicans biofilm formation in vitro and in vivo. Eukaryotic Cell. 6:931-939. doi: 10.1128/EC.00049-07.

Metallo, C. M., J. C. Mohr, C. J. Detzel, J. J. de Pablo, B. J. Van Wie, and Palecek, S.P. 2007. Engineering the stem cell microenvironment. Biotechnol. Prog. 23:18-23. doi: 10.1021/bp060350a.

2006

Benton, M. G., S. Somasundaram, J. D. Glasner, and Palecek, S.P. 2006. Analyzing the dose-dependence of the Saccharomyces cerevisiae global transcriptional response to methyl methanesulfonate and ionizing radiation. BMC Genomics. 7:305. doi: 10.1186/1471-2164-7-305.

Ji, L., B. L. Allen-Hoffmann, J. J. De Pablo, and Palecek, S.P. 2006. Generation and differentiation of human embryonic stem cell-derived keratinocyte precursors. Tissue Eng. 12:665-679.

Karlsson, A. J., W. C. Pomerantz, B. Weisblum, S. H. Gellman, and Palecek, S.P. 2006. Antifungal activity from 14-helical beta-peptides. J. Am. Chem. Soc. 128:12630-12631. doi: 10.1021/ja064630y.

Mohr, J. C., J. J. de Pablo, and Palecek, S.P. 2006. Electroporation of human embryonic stem cells: Small and macromolecule loading and DNA transfection. Biotechnol. Prog. 22:825-834. doi: 10.1021/bp0600334.

Mohr, J. C., J. J. de Pablo, and Palecek, S.P. 2006. 3-D microwell culture of human embryonic stem cells. Biomaterials. 27:6032-6042. doi: 10.1016/j.biomaterials.2006.07.012.

Saha, S., J. Lin, J. J. De Pablo, and Palecek, S.P. 2006. Inhibition of human embryonic stem cell differentiation by mechanical strain. J. Cell. Physiol. 206:126-137. doi: 10.1002/jcp.20441.

2005

Brueggemeier, S. B., S. J. Kron, and Palecek, S.P. 2005. Protein-acrylamide copolymer hydrogels for parallel analysis of protein-protein interactions. Abstracts of Papers of the American Chemical Society. 229:328-BIOT.

Brueggemeier, S. B., D. Wu, S. J. Kron, and Palecek, S.P. 2005. Protein-acrylamide copolymer hydrogels for array-based detection of tyrosine kinase activity from cell lysates. Biomacromolecules. 6:2765-2775. doi: 10.1021/bm050257v.

Li, F., and Palecek, S.P. 2005. Identification of Candida albicans genes that induce Saccharomyces cerevisiae cell adhesion and morphogenesis. Biotechnol. Prog. 21:1601-1609. doi: 10.1021/bp050236c.

Nie, Y., J. J. de Pablo, and Palecek, S.P. 2005. Platelet cryopreservation using a trehalose and phosphate formulation. Biotechnol. Bioeng. 92:79-90.

Svarovsky, M. J., and Palecek, S.P. 2005. Disruption of LRGI inhibits mother-daughter separation in Saccharomyces cerevisiae. Yeast. 22:1117-1132. doi: 10.1002/yea.1301.

2004

Brueggemeier, S. B., S. J. Kron, and Palecek, S.P. 2004. Use of protein-acrylamide copolymer hydrogels for measuring protein concentration and activity. Anal. Biochem. 329:180-189. doi: 10.1016/j.ab.2004.02.012.

Brueggemeier, S. B., and Palecek, S.P. 2004. Development of protein-acrylamide copolymer hydrogels for protein arrays. Abstracts of Papers of the American Chemical Society. 227:136-BIOT.

Chambers, P., A. Issaka, and Palecek, S.P. 2004. Saccharomyces cerevisiae JEN1 promoter activity is inversely related to concentration of repressing sugar. Appl. Environ. Microbiol. 70:8-17. doi: 10.1128/AEM.70.1.8-17.2004.

Chow, C. K., and Palecek, S.P. 2004. Enzyme encapsulation in permeabilized Saccharomyces cerevisiae cells. Biotechnol. Prog. 20:449-456. doi: 10.1021/bp034216r.

Ji, L., J. J. de Pablo, and Palecek, S.P. 2004. Cryopreservation of adherent human embryonic stem cells. Biotechnol. Bioeng. 88:299-312.

Saha, S., L. Ji, J. C. Mohr, J. J. de Pablo, and Palecek, S.P. 2004. Effect of thermal and mechanical stresses on human embryonic stem cell growth and differentiation. Abstracts of Papers of the American Chemical Society. 227:120-BIOT.

2003

Brueggemeier, S. B., and Palecek, S.P. 2003. Stable surface attachment and detection of fusion proteins. Abstracts of Papers of the American Chemical Society. 225:313-BIOT.

Li, F., and Palecek, S.P. 2003. EAP1, a Candida albicans gene involved in binding human epithelial cells. Eukaryotic Cell. 2:1266-1273. doi: 10.1128/EC.2.6.1266-1273.2003.